PerspectiveCell Biology

Tickling Macrophages, a Serious Business

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Science  21 May 2004:
Vol. 304, Issue 5674, pp. 1123-1124
DOI: 10.1126/science.1099161

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Failure to remove apoptotic cells and cell debris has been linked to the development of autoimmunity. In their Perspective, Züllig and Hengartner discuss a study from Nagata and colleagues that identifies a crucial bridging protein, MFG-E8, as essential for the removal of apoptotic cells ( Hanayama et al.).