Reviewing Hormone Replacement Therapy

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Science  28 May 2004:
Vol. 304, Issue 5675, pp. 1207
DOI: 10.1126/science.304.5675.1207g

Many women have received hormone replacement therapy to alleviate symptoms associated with menopause. As an added benefit, steroid hormones were thought to reduce the risk of coronary heart disease and prevent bone loss in women. A large-scale clinical trial, termed the Women's Health Initiative (WHI), aimed to determine the risks and benefits of hormone replacement therapy. Turgeon et al. (p. 1269) review the WHI data based on what is known about the molecular interactions and pharmacology of replacement hormones. The relative risks and benefits revealed by the WHI study should only be considered in the light of the experimental design used.

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