Regenerating Lost Germline Stem Cells

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Science  28 May 2004:
Vol. 304, Issue 5675, pp. 1207
DOI: 10.1126/science.304.5675.1207i

The invertebrate germ line is an excellent model system to elucidate stem cell biology. Jak-STAT signaling maintains germline stem cell self-renewal in Drosophila testis. Brawley and Matunis (p. 1331, published online 13 May 2004) now find that removing and then restoring Jak-STAT signaling in this system results in the regeneration of lost germline stem cells. These stem cells arise from the dedifferentiation of clusters of interconnected spermatogonial cells. Thus, even after spermatogonia have initiated differentiation, under the right conditions they can revert to germline stem cells.

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