Crossing the Midline

Science  04 Jun 2004:
Vol. 304, Issue 5676, pp. 1455-1456
DOI: 10.1126/science.1099534

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How do axons in the developing central nervous system know when and how to cross the midline to reach their neuronal targets on the other side. In his Perspective, Woods discusses the latest finding that the Robo3 receptor expressed by the growing axon tip releases inhibition of the chemoattractant Netrin, resulting in attraction of the axon tip to the midline ( Jen et al.). Once the axon tip has crossed the midline, decreased expression of the Robo3 receptor ensures that the tip does not recross the midline.