Report

A Process for Controlling Intracellular Bacterial Infections Induced by Membrane Injury

+ See all authors and affiliations

Science  04 Jun 2004:
Vol. 304, Issue 5676, pp. 1515-1518
DOI: 10.1126/science.1098371

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Strategies for inhibiting phagolysosome fusion are essential for the intracellular survival and replication of many pathogens. We found that the lysosomal synaptotagmin Syt VII is required for a mechanism that promotes phagolysosomal fusion and limits the intracellular growth of pathogenic bacteria. Syt VII was required for a form of Ca2+-dependent phagolysosome fusion that is analogous to Ca2+-regulated exocytosis of lysosomes, which can be triggered by membrane injury. Bacterial type III secretion systems, which permeabilize membranes and cause Ca2+ influx in mammalian cells, promote lysosomal exocytosis and inhibit intracellular survival in Syt VII +/+ but not –/– cells. Thus, the lysosomal repair response can also protect cells against pathogens that trigger membrane permeabilization.

    View Full Text

    Related Content