PerspectiveDevelopmental Biology

A Linker Histone Restricts Muscle Development

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Science  11 Jun 2004:
Vol. 304, Issue 5677, pp. 1607-1609
DOI: 10.1126/science.1099577

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Much chromatin research has centered on modifications to the core histones that regulate gene expression. In their Perspective, Cirillo and Zaret discuss new findings that highlight a fifth type of histone, the linker histone H1, which is now shown to work with the Msx1 homeodomain protein to regulate the differentiation of muscle progenitor cells ( Lee et al.).