PerspectiveDevelopmental Biology

Hox Genes in the Limb: A Play in Two Acts

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Science  11 Jun 2004:
Vol. 304, Issue 5677, pp. 1610-1611
DOI: 10.1126/science.1099162

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The development of the tetrapod limb depends on complex cascades of gene expression. In her Perspective, Deschamps reports on a new study ( Zákány et al.) that dissects the expression patterns and functions of the HoxD gene cluster during the early stages of limb bud development in the mouse.