DATABASE: Profiling Cancer Cells

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Science  18 Jun 2004:
Vol. 304, Issue 5678, pp. 1725
DOI: 10.1126/science.304.5678.1725c

Faulty genes can spur cancer, but tumor cells also show changes in the activity of other, undamaged genes. Researchers seeking patterns in the genes expressed in cancer cells have a new tool called Oncomine, a clearinghouse of data from assays known as microarrays. Oncomine's creators at the University of Michigan and in Bangalore, India, hope to amass all cancer microarray data from the literature. So far, the site unites results from 65 studies on 18 cancer types, from adrenal to uterine. Users can find out which genes speed up or slow down their activity in each type of tumor or compare activity profiles for different cancers. The site requires registration, which is free for academic users.

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