DATABASE: Bioactives Cookbook

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Science  25 Jun 2004:
Vol. 304, Issue 5679, pp. 1883
DOI: 10.1126/science.304.5679.1883e

This new site from the Center for Chemical Methodology and Library Development makes it easier to cook up bioactives—molecules with biological effects that might help researchers craft drugs and probe cells' workings. The site from Boston University features interactive protocols for synthesizing 50 such molecules. You enter the quantity of each compound you want to make, and a calculator tells you how much of each reactant to add. Then just follow the step-by-step instructions for carrying out the synthesis, and voilà, you've got a batch of chiral maleimide, or C33H28BrNO7. The site will expand as the center's chemists develop new protocols.

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