De Novo Design of an Enzyme

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Science  25 Jun 2004:
Vol. 304, Issue 5679, pp. 1916-1917
DOI: 10.1126/science.1100482

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Enzymes catalyze biological reactions with amazing efficiency, and years of biochemical research have been directed at understanding how they work. In their Perspective, Sterner and Schmid describe recent work ( Dwyer et al. ) that brings us closer to the ultimate goal of designing enzymes with tailored activities by using computer design to build catalytic activity onto an inert protein scaffold.