Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene

+ See all authors and affiliations

Science  25 Jun 2004:
Vol. 304, Issue 5679, pp. 1983-1986
DOI: 10.1126/science.1095943

You are currently viewing the abstract.

View Full Text


Endogenous opioid binding to μ receptors is hypothesized to mediate natural rewards and has been proposed to be the basis of infant attachment behavior. Here, we report that μ-opioid receptor knockout mouse pups emit fewer ultrasonic vocalizations when removed from their mothers but not when exposed to cold or male mice odors. Moreover these knockout pups do not show a preference toward their mothers' cues and do not show ultrasonic calls potentiation after brief maternal exposure. Results from this study may indicate a molecular mechanism for diseases characterized by deficits in attachment behavior, such as autism or reactive attachment disorder.

View Full Text

Related Content