PerspectiveCell Biology

The Golgi Goes Fission

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Science  02 Jul 2004:
Vol. 305, Issue 5680, pp. 48-49
DOI: 10.1126/science.1100153

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Like other cellular organelles, the Golgi apparatus has to be divided equally between the two daughter cells that result from mitosis. The first step in this process is fragmentation of the Golgi, followed by fission of the Golgi membranes during early mitosis. As Diao and Lowe discuss in their Perspective, new findings ( Hidalgo Carcedo et al.) show that Golgi membrane fission induced by the CtBP3/BARS protein is required before cells can enter mitosis.