Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia

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Science  02 Jul 2004:
Vol. 305, Issue 5680, pp. 90-93
DOI: 10.1126/science.1098925

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Analysis of developmental plasticity of bone marrow–derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with β-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.

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