Tracing an Orphan's Genealogy

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Science  09 Jul 2004:
Vol. 305, Issue 5681, pp. 185-187
DOI: 10.1126/science.1100890

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Immunologists have long thought that certain populations of intraepithelial T lymphocytes (IELs) are born and raised in the gut mucosa. A new twist on the origin of IELs is provided by Guy-Grand and Vassalli in their Perspective, which discusses new work (Eberl and Littman) identifying the thymus as the birthplace of IELs.

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