PerspectiveMolecular Biology

Unraveling DNA Condensation with Optical Tweezers

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Science  09 Jul 2004:
Vol. 305, Issue 5681, pp. 188-190
DOI: 10.1126/science.1100603

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Summary

Optical tweezers have revealed remarkable molecular details about cellular events, ranging from the movement of protein motors along molecular tracks to the unfolding pathways of RNA. In her Perspective, Zhuang introduces us to a new study ( Case et al.) in which optical tweezers are used to elucidate how condensin proteins help DNA to take on the condensed form that is essential for proper cell division.