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Exploiting Tolerance Processes in Transplantation

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Science  09 Jul 2004:
Vol. 305, Issue 5681, pp. 209-212
DOI: 10.1126/science.1099538

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The full potential of organ transplantation has not yet been realized because of the hazards associated with the long-term use of immunosuppressive drugs. Modern research into mechanisms of immune tolerance offers the promise of reprogramming the immune system, so as to harness the body's natural tolerance mechanisms in the service of graft acceptance. This would allow the minimization of immunosuppressive treatment and offers the prospect of eventually weaning transplant recipients off their drugs.

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