Epileptic Neurons Go Wireless

Science  23 Jul 2004:
Vol. 305, Issue 5683, pp. 482-483
DOI: 10.1126/science.1101133

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Neuroscientists have long been puzzled by the fact that prolonged epileptic seizures facilitate future seizures. In his Perspective, Staley discusses a recent study in a rat model of temporal lobe epilepsy ( Bernard et al.), which shows that a contributory factor to this facilitation is the loss of inhibitory Kion currents called A currents.