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The Complete Genome Sequence of Propionibacterium Acnes, a Commensal of Human Skin

Science  30 Jul 2004:
Vol. 305, Issue 5684, pp. 671-673
DOI: 10.1126/science.1100330

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Abstract

Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes–associated diseases.

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