TOOLS: DNA Surfing

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Science  06 Aug 2004:
Vol. 305, Issue 5685, pp. 759
DOI: 10.1126/science.305.5685.759e

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Like a good tour guide, the Gene Resource Locator can help you find the highlights of the mouse and human genomes. Hosted by the University of Tokyo, the site lets you scroll through individual chromosomes to locate features such as exons (noncoding DNA), introns (coding DNA), common mutations known as SNPs, and matches for expressed sequence tags: snippets of DNA used as tools to pinpoint genes or gauge their activity. You can pick out sequences whose RNA might undergo alternative splicing, creating different proteins. To find out whether a gene is switched on in a particular tissue, link to the BodyMap gene activity database.

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