TOOLS: A Clockwork Fungus

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Science  13 Aug 2004:
Vol. 305, Issue 5686, pp. 925
DOI: 10.1126/science.305.5686.925b

A baroque network of more than 20 interacting proteins governs the growth and reproduction of yeast cells. Researchers can probe this complex system by running a model crafted by researchers at Virginia Tech University in Blacksburg. Their site, launched to accompany a paper in the August issue of Molecular Biology of the Cell, includes an interactive diagram of the yeast control network; click on a protein to get information on its function, regulation, and activation, along with relevant references. A table indicates how more than 100 mutations alter the yeast cell cycle. Users can run the model online after downloading free software.

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