NAD to the Rescue

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Science  13 Aug 2004:
Vol. 305, Issue 5686, pp. 954-955
DOI: 10.1126/science.1102497

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Identified 15 years ago, the Wld mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, Simon discusses new work ( Araki et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.