PerspectiveImmunology

UNGstoppable Switching

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Science  20 Aug 2004:
Vol. 305, Issue 5687, pp. 1113-1114
DOI: 10.1126/science.1102692

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Summary

The enzymes AID, a DNA deaminase, and UNG are crucial for two processes (CSR and SHM) involved in the generation of antibody diversity in B cells. As Unniraman and colleagues point out in their Perspective, new findings about the action of UNG suggest a rethink of a popular model of CSR in which the central event is DNA deamination by AID ( Begum et al.)