Cell Biology

Ribbons and Bows

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Science  27 Aug 2004:
Vol. 305, Issue 5688, pp. 1215
DOI: 10.1126/science.305.5688.1215c

The Golgi complex in mammalian cells resides in a juxtanuclear position that depends on the centrosome and on microtubules. How is this single Golgi ribbon produced, and how does it “know” to form at the periphery of the centrosome? Rios et al. find that the protein GMAP-210, peripherally associated with cis- (the side facing the nucleus) Golgi membranes, binds to microtubules and promotes the recruitment of -tubulin- containing complexes to the Golgi. Reduction of GMAP-210 levels causes the fragmentation of the Golgi complex and interferes with membrane traffic. The ability of GMAP-210 to recruit organelles to the centrosomal region can be transferred—when GMAP-210, or only its C-terminal domain, was engineered to insert into the mitochondrial membrane, the mitochondria recruited -tubulin and moved toward the centrosome. Thus, GMAP-210 appears to play an organizing role in the generation and maintenance of a single, central Golgi complex. — SMH

Cell 118, 323 (2004).

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