DATABASE: Protein Matchmaking

Science  03 Sep 2004:
Vol. 305, Issue 5689, pp. 1381b
DOI: 10.1126/science.305.5689.1381b

This collection of more than 50,000 protein structures provides a speedy way to contrast similar molecules. ProteinDBS lets you enter a Protein DataBank ID number or file of coordinates for a molecule such as carbonic anhydrase (left), which helps rid the body of carbon dioxide from metabolism. The search finds the 50 proteins most like your choice and allows you to make visual and statistical comparisons. For instance, you can superimpose three- dimensional portraits of two proteins or parse their sequences amino acid by amino acid. The site comes from computer scientist Chi-Ren Shyu of the University of Missouri, Columbia, and colleagues.

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