PerspectiveMolecular Biology

Argonaute Journeys into the Heart of RISC

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Science  03 Sep 2004:
Vol. 305, Issue 5689, pp. 1409-1410
DOI: 10.1126/science.1103076

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Identifying the "slicer" component of the RNA-induced silencing complex (RISC) complex has been a major goal of those interested in the RNA interference pathway of gene silencing. In their Perspective, Sontheimer and Carthew discuss a pair of recent studies ( Liu et al., Song et al.) that identify the protein Argonaute2 as the slicer element of RISC that cleaves target messenger RNAs.