Targeting Apoptotic Pathways in Cancer Cells

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Science  03 Sep 2004:
Vol. 305, Issue 5689, pp. 1411-1413
DOI: 10.1126/science.1102974

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A holy grail of cancer therapy has been to design peptidomimetics-small peptides containing nonnatural amino acids-that bind to target proteins and induce cancer cells to undergo apoptosis. In their Perspective, Denicourt and Dowdy discuss two new innovative strategies ( Li et al., Walensky et al.) for designing peptidomimetics that target protein-protein interactions in the extrinsic and intrinsic pathways of apoptotic cell death.