TOOLS: Getting More Out of Gene Chips

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Science  10 Sep 2004:
Vol. 305, Issue 5690, pp. 1543b
DOI: 10.1126/science.305.5690.1543b

Microarrays yield prodigious amounts of data on gene activity, but the sheer volume can leave researchers asking, “What does it all mean biologically?” says molecular pharmacologist John Weinstein of the National Cancer Institute. This collection of tools crafted by Weinstein and colleagues can help the flummoxed winnow their results. For example, MatchMiner copes with what Weinstein calls genomics's “Tower of Babel”: Different databases and gene chip-makers often apply different names to the same gene. Multilingual MatchMiner can translate between, say, GenBank and Unigene nomenclature. Another tool, GoMiner, helps collate and interpret genes by function. The site's newest offering, based on the team's paper last month in Cancer Cell, lets you download and analyze expression profiles for the ABC transporter genes. Some of these genes help tumors evade cancer drugs.

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