PerspectiveStructural Biology

Evolution of RNA Architecture

Science  01 Oct 2004:
Vol. 306, Issue 5693, pp. 62-63
DOI: 10.1126/science.1104482

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Crystal structures of different RNA molecules and of ribonucleoprotein particles such as the ribosome are casting new light on the intricacies of RNA structure, folding, and evolution. In their Perspective, Westhof and Massire discuss new work ( Krasilnikov et al.) that highlights striking differences in the secondary structure of type A and type B RNAs of the bacterial endonuclease ribonuclease P, which nevertheless do the same job.