DATABASE: Sorting Out Disease Genes

See allHide authors and affiliations

Science  08 Oct 2004:
Vol. 306, Issue 5694, pp. 205
DOI: 10.1126/science.306.5694.205e

Many disease-spurring genes are hard to finger because their impact is subtle or they conspire with other genes. The new Genetic Association Database from the National Institute on Aging (NIA) compiles evidence for and against more than 1700 genes with mutations, or polymorphisms, thought to be involved in common diseases. The hand-curated site links to PubMed abstracts of more than 5600 studies that have gauged the genes' effects on various disorders, from colon polyps to hay fever. The entries also connect to a host of gene databases and other information sources. For instance, some listings allow you to scan an NIA biochemistry database to find out which metabolic pathways the gene participates in. You can also limit your search to studies with positive findings.

Navigate This Article