PerspectiveMolecular Biology

RNAs Turn On in Tandem

See allHide authors and affiliations

Science  08 Oct 2004:
Vol. 306, Issue 5694, pp. 233-234
DOI: 10.1126/science.1104975

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The activity of many proteins is regulated allosterically such that a small molecule binding to a site distant from the active site alters the conformation of the active site and hence its activity. In his Perspective, Famulok discusses the discovery of a bacterial riboswitch composed of two RNA molecules in the untranslated region of messenger RNAs that, when both bound by glycine, allosterically regulate genes controlling glycine metabolism ( Mandal et al.).