PerspectiveMolecular Biology

RNAs Turn On in Tandem

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Science  08 Oct 2004:
Vol. 306, Issue 5694, pp. 233-234
DOI: 10.1126/science.1104975

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The activity of many proteins is regulated allosterically such that a small molecule binding to a site distant from the active site alters the conformation of the active site and hence its activity. In his Perspective, Famulok discusses the discovery of a bacterial riboswitch composed of two RNA molecules in the untranslated region of messenger RNAs that, when both bound by glycine, allosterically regulate genes controlling glycine metabolism ( Mandal et al.).