Resources: Molecules Make a Move

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Science  15 Oct 2004:
Vol. 306, Issue 5695, pp. 383
DOI: 10.1126/science.306.5695.383c

Proteins and other big molecules look stiff and static on the printed page, but in living cells, their twisting, bending, and flexing help them perform their jobs. Watch the action at the Database of Macromolecular Movements from bioinformatics maven Mark Gerstein of Yale University and colleagues. The site's animations portray the gymnastics of more than 100 proteins and RNA molecules, such as the cytochrome BC1 complex, which plays a key role in oxidative respiration. The flicks can clarify a molecule's function and help drug designers craft more potent compounds. If you have a sample that's not in the database, plug your data into the site's free software to animate its twists and turns.

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