Essays on Science and SocietyEPPENDORF ESSAY WINNER

Deconstructing C. elegans Sensory Mechanotransduction

Science  15 Oct 2004:
Vol. 306, Issue 5695, pp. 427-428
DOI: 10.1126/science.1105624

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Much important information reaches us through the sense of touch, yet little is known about the protein machinery that converts mechanical energy into electrical responses at neurons. In her prize-winning essay, Miriam Goodman describes work aimed at understanding mechanotransduction in C. elegans. She describes characterization of an ion channel complex that is likely at the core of the transduction complex and gated by mechanical energy.