Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

See allHide authors and affiliations

Science  22 Oct 2004:
Vol. 306, Issue 5696, pp. 704-708
DOI: 10.1126/science.1099962

You are currently viewing the abstract.

View Full Text


Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB translocation. Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-κB signaling may thus depend on number, period, and amplitude of oscillations.

View Full Text