How Active Sites Communicate in Thiamine Enzymes

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Science  29 Oct 2004:
Vol. 306, Issue 5697, pp. 818-820
DOI: 10.1126/science.1105457

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Thiamine enzymes require thiamine in its diphosphate form as a cofactor. In his Perspective, Jordan discusses a new study that highlights how the active sites of thiamine enzymes communicate ( Frank et al.).