DATABASE: Dealing Gene Data

See allHide authors and affiliations

Science  05 Nov 2004:
Vol. 306, Issue 5698, pp. 951
DOI: 10.1126/science.306.5698.951e

Shuffling through GeneCards from the Weizmann Institute of Science in Israel can help you discover the latest information on human genes and proteins and the diseases that result when they go awry. The site's deck includes nearly 39,000 cards—seen as Web pages—profiling all of the human genes that have received official names, along with many others. For example, if you draw the card for BRCA1, which is mutated in some kinds of inherited breast cancer, you will get data on the gene's location and sequence. The card also summarizes information on the protein's structure and actions, drawing information from sites such as SwissProt and the Gene Ontology Consortium.

In addition, you can perform broader searches to identify all the genes that reside on a chromosome or that participate in a particular disease or process, such as cellular suicide, known as apoptosis. The cards also link to other Weizmann Institute databases such as GeneNote, which features gene-expression results from healthy tissues, and GeneTide, which can help pin down new genes. The site is free for academic researchers.

Navigate This Article