TOOLS: Worm Genomics Sampler

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Science  19 Nov 2004:
Vol. 306, Issue 5700, pp. 1269
DOI: 10.1126/science.306.5700.1269b

For their size, parasitic nematodes are disproportionately destructive, ruining more than $80 billion worth of crops around the world each year and causing diseases such as filariasis and trichinosis. Nematode.Net, hosted by Washington University in St. Louis, Missouri, supplies tools for analyzing genomic data from a long list of mainly parasitic worms. The site corrals more than 240,000 expressed sequence tags (ESTs), DNA snippets that can help researchers pinpoint which genes a worm carries. Using NemaBLAST, parasitologists, molecular biologists, and drug designers looking for a worm's weaknesses can hunt for particular sequences in more than 20 nematode species. A search tool lets you view clusters of overlapping ESTs, providing a clear picture of a nematode's genetic endowment.

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