PerspectiveMolecular Biology

Knives, Accomplices, and RNA

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Science  19 Nov 2004:
Vol. 306, Issue 5700, pp. 1299-1300
DOI: 10.1126/science.1100137

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There are many proteins known to cleave different types of RNAs, but it is not clear whether they all act separately or sometimes cooperate. In their Perspective, Wickens and Gonzalez discuss the search for the enzyme that cleaves pre-mRNAs to form the 3 ' end of mRNAs. They reveal the surprising finding that this enzyme colludes with the enzymes that cut pre-tRNAs.