Gastric Cancer Originating from Bone Marrow-Derived Cells

+ See all authors and affiliations

Science  26 Nov 2004:
Vol. 306, Issue 5701, pp. 1568-1571
DOI: 10.1126/science.1099513

You are currently viewing the abstract.

View Full Text


Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow–derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.

    View Full Text

    Related Content