Cell Biology

Metalloprotease, Migration, and Mitosis

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Science  10 Dec 2004:
Vol. 306, Issue 5703, pp. 1862
DOI: 10.1126/science.306.5703.1862b

The cell division cycle is controlled by the interplay of phosphorylation pathways and regulated proteolysis. McHugh et al. describe a new player involved in promoting mitotic progression—a metalloprotease they call invadolysin. Mutant Drosophila larvae lacking invadolysin display defects in nuclear and mitotic spindle morphology, and in addition exhibit abnormalities in the directed migration of germ cells. Invadolysin appears to act as a protease that degrades nuclear lamin proteins, whose disassembly is a key event at the beginning of mitosis. Generally, invadolysin is found localized in the cytoplasm in structures resembling invadopodia, which are found in invasive tumor cells munching their way through extracellular matrix. In migrating macrophages, invadolysin is concentrated at the leading edge, where it likely facilitates cell migration. — SMH

J. Cell Biol. 167, 673 (2004).

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