Report

Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte

See allHide authors and affiliations

Science  10 Dec 2004:
Vol. 306, Issue 5703, pp. 1930-1933
DOI: 10.1126/science.1102452

You are currently viewing the abstract.

View Full Text

Abstract

To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to ∼8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.

    View Full Text