TB--A New Target, a New Drug

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Science  14 Jan 2005:
Vol. 307, Issue 5707, pp. 214-215
DOI: 10.1126/science.1108379

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Tuberculosis (TB) kills 2 million people annually worldwide and imposes huge costs on communities, particularly those in developing countries. Yet no new drugs for TB have been discovered in the past 40 years. This is set to change, as Cole and Alzari report in their Perspective, with the discovery of a diarylquinoline compound that is highly active against a broad range of mycobacterial species including both the drug-sensitive and drug-resistant forms of M. tuberculosis, the bacterium that causes TB ( Andries et al.).