PerspectiveCell Signaling

Stat Acetylation--A Key Facet of Cytokine Signaling?

Science  14 Jan 2005:
Vol. 307, Issue 5707, pp. 217-218
DOI: 10.1126/science.1108164

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Summary

Modification of proteins by addition of, for example, phosphate groups to particular amino acids in the protein is an important way to regulate the protein's activity. In their Perspective, O'Shea and colleagues discuss the intriguing finding that addition of an acetyl group to an amino acid in an important group of transcription factors called Stats might regulate their activity ( Yuan et al.).

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