Viewpoint

How Obesity Causes Diabetes: Not a Tall Tale

Science  21 Jan 2005:
Vol. 307, Issue 5708, pp. 373-375
DOI: 10.1126/science.1104342

You are currently viewing the abstract.

View Full Text

Abstract

The epidemic of obesity-associated diabetes is a major crisis in modern societies, in which food is plentiful and exercise is optional. The biological basis of this problem has been explored from evolutionary and mechanistic perspectives. Evolutionary theories, focusing on the potential survival advantages of “thrifty” genes that are now maladaptive, are of great interest but are inherently speculative and difficult to prove. Mechanistic studies have revealed numerous fat-derived molecules and a link to inflammation that, together, are hypothesized to underlie the obesity-diabetes connection and thereby represent prospective targets for therapeutic intervention.

View Full Text

Cited By...