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Mitochondrial Dysfunction and Type 2 Diabetes

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Science  21 Jan 2005:
Vol. 307, Issue 5708, pp. 384-387
DOI: 10.1126/science.1104343

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Maintenance of normal blood glucose levels depends on a complex interplay between the insulin responsiveness of skeletal muscle and liver and glucose-stimulated insulin secretion by pancreatic β cells. Defects in the former are responsible for insulin resistance, and defects in the latter are responsible for progression to hyperglycemia. Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction.

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