Proliferation of Functional Hair Cells in Vivo in the Absence of the Retinoblastoma Protein

Cyrille Sage; Mingqian Huang; Kambiz Karimi; Gabriel Gutierrez; Melissa A. Vollrath; Duan-Sun Zhang; Jaime García-Añoveros; Philip W. Hinds; Jeffrey T. Corwin; David P. Corey; Zheng-Yi Chen

doi:10.1126/science.1106642

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Abstract

In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.

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Science

Vol 307, Issue 5712
18 February 2005

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Proliferation of Functional Hair Cells in Vivo in the Absence of the Retinoblastoma Protein

By Cyrille Sage, Mingqian Huang, Kambiz Karimi, Gabriel Gutierrez, Melissa A. Vollrath, Duan-Sun Zhang, Jaime García-Añoveros, Philip W. Hinds, Jeffrey T. Corwin, David P. Corey, Zheng-Yi Chen

Science18 Feb 2005 : 1114-1118

Inactivation of a differentiation-related protein in inner ear cells can restore their ability to regenerate, suggesting a potential treatment for hearing loss.

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Proliferation of Functional Hair Cells in Vivo in the Absence of the Retinoblastoma Protein

By Cyrille Sage, Mingqian Huang, Kambiz Karimi, Gabriel Gutierrez, Melissa A. Vollrath, Duan-Sun Zhang, Jaime García-Añoveros, Philip W. Hinds, Jeffrey T. Corwin, David P. Corey, Zheng-Yi Chen

Science18 Feb 2005 : 1114-1118

Inactivation of a differentiation-related protein in inner ear cells can restore their ability to regenerate, suggesting a potential treatment for hearing loss.

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