A Pathogen Attacks While Keeping Up Defense

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Science  25 Feb 2005:
Vol. 307, Issue 5713, pp. 1211-1212
DOI: 10.1126/science.1109836

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Certain species of Shigella and Yersinia bacteria are serious human pathogens. In a Perspective, Normark and colleagues discuss two exciting studies ( West et al., Mota et al.) that shed light on the mechanisms enabling Shigella and Yersinia to invade host target cells. The new work may pave the way to designing new therapeutics to block invasion of host cells by these human pathogens.