DATABASE: Breaking Down Diabetes

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Science  04 Mar 2005:
Vol. 307, Issue 5714, pp. 1385
DOI: 10.1126/science.307.5714.1385b

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The immune system runs amok in type I diabetes and rubs out insulin-making cells in the pancreas, sabotaging the body's ability to control glucose levels. The site T1DBase dispenses the latest information about genes implicated in this disease in rats, mice, and humans. Search the collection by chromosome or by name to dig up data about a particular gene. Plugging your selection into the tool Gbrowse lets you parse the gene's structure and see landmarks such as single nucleotide polymorphisms and repeated sequences. The entries also indicate which biochemical pathways the gene plays a role in and often provide measurements of its activity in different tissues. Another feature helps users sort through the sometimes-baffling genomic terminology by translating the various designations that different databases apply to the same genes. The site is sponsored by the Institute for Systems Biology in Seattle, Washington, and other organizations.

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