DATABASE: Standard of Normalcy

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Science  11 Mar 2005:
Vol. 307, Issue 5715, pp. 1539
DOI: 10.1126/science.307.5715.1539d

Some genes crank up their activity in illnesses such as cancer and atherosclerosis, while others get lazy. To identify these changes in activity patterns, researchers need to know how hard the genes work in healthy tissue. Aimed at cancer researchers, drug designers, and other scientists, the new Oncogenomics Normal Tissue Database from the National Cancer Institute provides the baseline data for comparison. After completing a free registration, users can delve into expression results for nearly 19,000 genes in 19 organs, from the adrenal glands to the uterus. The collection caches microarray measurements on fresh tissue samples from apparently hale people who died between the ages of 3 months and 39 years, and the gene roster includes most of the ones that keep cells operating.

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