PerspectiveCell Biology

Ras on the Roundabout

+ See all authors and affiliations

Science  18 Mar 2005:
Vol. 307, Issue 5716, pp. 1731-1733
DOI: 10.1126/science.1110551

You are currently viewing the summary.

View Full Text

Summary

H-Ras, N-Ras, and K-Ras are homologous signaling molecules that are able to regulate distinct signaling pathways because they inhabit different compartments within the cell. In their Perspective, Meder and Simons discuss new work ( Rocks et al.) showing that N-Ras and H-Ras continuously cycle between the plasma membrane and Golgi membranes and that this trafficking depends on whether the Ras isoforms carry a palmitoyl group.