DATABASE: Taking Aim at CREB

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Science  01 Apr 2005:
Vol. 308, Issue 5718, pp. 29c
DOI: 10.1126/science.308.5718.29c

By switching on certain genes, the cyclic AMP response element- binding protein (CREB) helps govern processes from cell metabolism to the wiring of the nervous system. Researchers can find out which genes the influential protein activates at the new CREB Target Gene Database from Marc Montminy of the Salk Institute in La Jolla, California, and colleagues. Users can determine whether their favorite gene carries a sequence that CREB recognizes and whether CREB actually latches onto the gene, among other info. The data are for humans, rats, and mice.

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